Electrophilic Agonists Modulate the Transient Receptor Potential Ankyrin-1 Channels Mediated by Insulin and Glucagon-Like Peptide-1 Secretion for Glucose Homeostasis

This pre-clinical study investigated the transient receptor potential ankyrin-1 (TRPA1) channels on modulating targets for glucose homeostasis using agonists: electrophilic agonists, cinnamaldehyde (CIN) and allyl isothiocyanate (AITC), non-electrophilic agonist, carvacrol (CRV). A tolerance test was performed rats. CIN AITC (5, 10 20 mg/kg) or CRV (25, 100, 300, 600 were administered intraperitoneally (i.p.), glycemia measured. In intestine, glucagon-like peptide-1 (GLP-1) disaccharidase activity evaluated (in vivo in vitro, respectively). Furthermore, vitro insulin secretion determined. Islets used to measure calcium influx. improved increased vitro. unable reduce glycemia. Electrophilic AITC, inhibited disaccharidases acted as secretagogues intestine by inducing GLP-1 release contributed The effect of influx pancreatic islets (insulin secretion) involves voltage-dependent from stores. TRPA1 triggers potentiates intracellular induce secretion, suggesting that agonists mediate this signaling transduction control